Kuroda S, Nakaya-Kishi Y, Tatematsu K, Hinuma S. 2023 Human olfactory receptor sensor for odor reconstitution. Sensors (Basel). 23 6164.
Cygnar KD, Zhao H. 2009 Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Nat. Neurosci. 12 454-462.
Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR. 1998 Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals. Neuron. 21 495-504.
Castillo K, Delgado R, Bacigalupo J. 2007 Plasma membrane Ca(2+)-ATPase in the cilia of olfactory receptor neurons: possible role in Ca(2+) clearance. Eur. J. Neurosci. 26 2524-2531.
Matarazzo V, Zsürger N, Guillemot JC, Clot-Faybesse O, Botto JM, Dal Farra C, Crowe M, Demaille J, Vincent JP, Mazella J, Ronin C. 2002 Porcine odorant-binding protein selectively binds to a human olfactory receptor. Chem. Senses. 27 691-701.
Nakashima N, Nakashima K, Taura A, Takaku-Nakashima A, Ohmori H, Takano M. 2020 Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons. Nat. Commun. 2020 11 2188.
Nakashima N, Nakashima K, Nakashima A, Takano M. 2020 Olfactory marker protein elevates basal cAMP concentration. Biochem. Biophys. Res. Commun. 531 203-208.
Mayberry CL, Wilczek MP, Fong TM, Nichols SL, Maginnis MS. 2021 GRK2 mediates β-arrestin interactions with 5-HT2 receptors for JC polyomavirus endocytosis. J. Virol. 95 e02139-20.
Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmüller J, Becker C, Schmidt A, Hatt H, Hummel T, Gisselmann G. 2013 Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One. 8 e54950.
Gisladottir RS, Ivarsdottir EV, Helgason A, Jonsson L, Hannesdottir NK, Rutsdottir G, Arnadottir GA, Skuladottir A, Jonsson BA, Norddahl GL, Ulfarsson MO, Helgason H, Halldorsson BV, Nawaz MS, Tragante V, Sveinbjornsson G, Thorgeirsson T, Oddsson A, Kristjansson RP, Bjornsdottir G, Thorgeirsson G, Jonsdottir I, Holm H, Gudbjartsson DF, Thorsteinsdottir U, Stefansson H, Sulem P, Stefansson K. 2020 Sequence variants in TAAR5 and other loci affect human odor perception and naming. Curr. Biol. 30 4643-4653.e3.
Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. 2004 The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature. 430 748-754.
Koivisto AP, Belvisi MG, Gaudet R, Szallasi A. 2022 Advances in TRP channel drug discovery: from target validation to clinical studies. Nat. Rev. Drug. Discov. 21 41-59.
Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P. 2014 Profiling of olfactory receptor gene expression in whole human olfactory mucosa. PLoS One. 9 e96333.
Olender T, Keydar I, Pinto JM, Tatarskyy P, Alkelai A, Chien MS, Fishilevich S, Restrepo D, Matsunami H, Gilad Y, Lancet D. 2016 The human olfactory transcriptome. BMC Genomics. 17 619.
Saraiva LR, Riveros-McKay F, Mezzavilla M, Abou-Moussa EH, Arayata CJ, Makhlouf M, Trimmer C, Ibarra-Soria X, Khan M, Van Gerven L, Jorissen M, Gibbs M, O’Flynn C, McGrane S, Mombaerts P, Marioni JC, Mainland JD, Logan DW. 2019 A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans. Sci. Adv. 5 eaax0396.
Marenco L, Wang R, McDougal R, Olender T, Twik M, Bruford E, Liu X, Zhang J, Lancet D, Shepherd G, Crasto C. 2016 ORDB, HORDE, ODORactor and other on-line knowledge resources of olfactory receptor-odorant interactions. Database (Oxford). 2016 baw132.
Liu X, Su X, Wang F, Huang Z, Wang Q, Li Z, Zhang R, Wu L, Pan Y, Chen Y, Zhuang H, Chen G, Shi T, Zhang J. 2011 ODORactor: a web server for deciphering olfactory coding. Bioinformatics. 27 2302-2303.
Sharma A, Saha BK, Kumar R, Varadwaj PK. 2022 OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant-receptor interactions. Nucleic Acids Res. 50(D1) D678-D686.
Cong X, Ren W, Pacalon J, Xu R, Xu L, Li X, de March CA, Matsunami H, Yu H, Yu Y, Golebiowski J. 2022 Large-scale G protein-coupled olfactory receptor-ligand pairing. ACS Cent. Sci. 8 379-387.
Sharma A, Kumar R, Semwal R, Aier I, Tyagi P, Varadwaj PK. 2022 DeepOlf: Deep neural network-based architecture for predicting odorants and their interacting olfactory receptors. IEEE/ACM Trans. Comput. Bio.l Bioinform. 19 418-428.
Qin C, Wang Y, Hu J, Wang T, Liu D, Dong J, Lu Y. 2023 Artificial olfactory biohybrid system: an evolving sense of smell. Adv. Sci. (Wein). 10 e2204726.
Son M, Cho DG, Lim JH, Park J, Hong S, Ko HJ, Park TH. 2015 Real-time monitoring of geosmin and 2-methylisoborneol, representative odor compounds in water pollution using bioelectronic nose with human-like performance. Biosens. Bioelectron. 74 199-206.
Son M, Kim D, Ko HJ, Hong S, Park TH. 2017 A portable and multiplexed bioelectronic sensor using human olfactory and taste receptors. Biosens. Bioelectron. 87 901-907.
Lee M, Yang H, Kim D, Yang M, Park TH, Hong S. 2018 Human-like smelling of a rose scent using an olfactory receptor nanodisc-based bioelectronic nose. Sci. Rep. 8 13945.
Castro JB, Ramanathan A, Chennubhotla CS. 2013 Categorical dimensions of human odor descriptor space revealed by non-negative matrix factorization. PLoS One. 8 e73289.
本稿では,感性指標化アーキテクチャに基づいた触感の定量化技術について,特に触感計測とプロダクトデザインでの活用事例を紹介した.さらにシボのテクスチャ触感を対象に,定量化により得られたモデルを数理計画法の枠組みで活用することで所望の触感を提供するハイトマップの生成が可能であることを示し,プロダクトデザインにおける触感定量化技術の有効性を示した.また,この取り組みは触覚情報のデジタル化に資するものである.著者らは,触感定量化技術に基づいた物性表現の枠組みとしてFDDF(Force-Displacement Distribution Function)を提案している(7).今後の展開として,触感を学習したよりヒトに近い感覚・感性構造を有するAIが実現され,これにより個人により最適なプロダクトやサービスのカスタマイズが可能になると期待される.また,この取り組を介して,一人ひとりの感性が尊重される社会,すなわち豊かで持続可能な社会の実現に貢献することができると考えている.
Y. Yamazaki, M. Imura, M. Nakatani, S. Osanai, N. Nagata, H. Tanaka, Feature quantification of material texture perception using a force-displacement relationship. Proc. 2021 IEEE World Haptics Conference (WHC), 1157 (2021)